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Updated: Mar 30, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
The TDIF signaling network
1Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Abstract:
Plant growth and development are coordinately controlled by intercellular signaling molecules. CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION-related (CLE) peptides are crucial intercellular signaling molecules that control plant meristem maintenance. CLE peptides are perceived by plasma membrane-located receptor-like kinases, followed by the initiation of intracellular signaling cascades. Recent studies have uncovered these intracellular signaling networks involving signal divergence and integration. This review summarizes recent advances in the study of TDIF peptide signaling pathway, a representative model of CLE peptide signaling, focusing on newly uncovered biological functions and unique signal transduction mechanisms.
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