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Updated: Mar 30, 2026

Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
Published on: March 16, 2016
Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
Marc Aurel Busche1,2,3, Christine Grienberger1,4, Aylin D Keskin1
1Institute of Neuroscience, Technische Universität München, Munich, Germany.
Abstract:
Among the most promising approaches for treating Alzheimer's disease is immunotherapy with amyloid-β (Aβ)-targeting antibodies. Using in vivo two-photon imaging in mouse models, we found that two different antibodies to Aβ used for treatment were ineffective at repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This unexpected finding provides a possible cellular explanation for the lack of cognitive improvement by immunotherapy in human studies.
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