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Peripheral quantitative computed tomography (pQCT) bone measurements in children with cystic fibrosis
Wei Bai1, Teresa L Binkley1, James W Wallace2
1EA Martin Program in Human Nutrition, SWC Box 506, South Dakota State University, South Dakota.
Insights
Children with cystic fibrosis (CF) exhibit reduced bone strength and cortical bone area, particularly in older individuals. Bone mineral content relative to lean mass remains similar to controls.
Area of Science:
- Pediatric Bone Health
- Cystic Fibrosis Research
- Skeletal Development
Background:
- Individuals with cystic fibrosis (CF) are known to have lower bone density and an increased risk of fractures.
- Understanding the specific skeletal characteristics in children with CF is crucial for early intervention and management.
Purpose of the Study:
- To investigate differences in whole body bone mineral content (WBBMC), bone geometry, and bone strength between children with CF and healthy controls.
- To examine the influence of age, height, and body composition on these skeletal parameters in pediatric CF.
Main Methods:
- A cross-sectional study was conducted comparing 12 children with CF to 23 age- and sex-matched controls.
- Measurements included whole body bone mineral content (WBBMC), bone geometry (periosteal and endosteal circumferences), and bone strength.
- Statistical analyses adjusted for age, height, and body composition to isolate the effects of CF.
Main Results:
- Children with CF had significantly lower WBBMC compared to controls (P=0.007), with more pronounced differences in older children.
- The CF group exhibited smaller periosteal and endosteal circumferences (P=0.02 for both).
- Cortical bone area and bone strength showed attenuated positive relationships with age in the CF group (P<0.01), indicating reduced bone development over time.
Conclusions:
- Children with CF demonstrate reduced cortical bone area and bone strength compared to controls, with these deficits becoming more apparent with increasing age.
- Despite lower overall bone mineral content, WBBMC relative to lean mass was comparable between the CF and control groups.
- These findings highlight specific skeletal vulnerabilities in pediatric CF, emphasizing the need for targeted bone health monitoring and interventions.
Background:
Individuals with cystic fibrosis (CF) have low bone density and increased fracture risk.
Methods:
Cross-sectional study investigating whole body bone mineral content (WBBMC), bone geometry and strength in 12 children with CF compared to 23 age- and sex-matched controls with and without adjusting for age, height, and body composition.
Results:
CF group had lower WBBMC than controls (P = 0.007) with larger differences at older ages (age-by-group, P = 0.08). CF group had decreased height (P = 0.006), a trend of lower lean mass per height (P = 0.08), and no difference in relationship between WBBMC and lean mass compared to controls (P = 0.65). Periosteal and endosteal circumferences were smaller in CF (each, P = 0.02). Positive relationships of cortical area and bone strength with age were attenuated with CF (group-by-age; each, P < 0.01).
Conclusion:
Children with CF have similar WBBMC relative to lean mass as controls. Cortical bone area and bone strength were less in CF group compared to controls, with greater differences in older children.
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