Related Experiment Video
Updated: Mar 30, 2026
06:41
A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
Published on: March 9, 2015
9.6K
Current Treatments for Alopecia Areata
1Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA.
The Journal of Investigative Dermatology. Symposium Proceedings
|November 10, 2015
Summary
Alopecia areata (AA) treatment selection considers patient factors and comorbidities. While no cure exists, emerging JAK inhibitors and IL-2 therapies show promise for managing this autoimmune hair loss condition.
Area of Science:
- Dermatology and Autoimmune Diseases
- Clinical and Translational Research
Background:
- Alopecia areata (AA) is an autoimmune condition with no definitive cure.
- Treatment decisions for AA involve patient age, disease severity, duration, expectations, cost, and screening for comorbidities.
- Scalp biopsy can inform treatment for extensive, long-standing AA by assessing inflammation and follicle differentiation.
Purpose of the Study:
- To review current approaches to alopecia areata therapy selection.
- To highlight emerging systemic therapies for AA management.
- To discuss the role of recent research in advancing AA treatment options.
Main Methods:
- Review of clinical and translational research findings.
- Analysis of factors influencing therapeutic choices in AA.
- Discussion of novel systemic agents and their clinical application.
Main Results:
- Current AA therapy selection is multifactorial, balancing patient-specific needs with clinical guidelines.
- Systemic Janus kinase (JAK) inhibitors and interleukin-2 (IL-2) are generating significant interest.
- These targeted therapies are progressing through clinical trials and off-label use for AA.
Conclusions:
- Effective management of alopecia areata requires a personalized approach.
- Emerging targeted therapies like JAK inhibitors and IL-2 represent a significant advancement in AA treatment.
- Continued research is crucial for developing sustained remission strategies for AA.
Related Concept Videos
01:27Acne Infection
48
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
48
01:30Skin Cancer
6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
6.6K
02:49Cancer Therapies
10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K
01:22Alzheimer's Disease: Treatment
1.2K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.2K
01:20Accessory Structures of the Skin: Hair Growth and Types
3.1K
Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
3.1K
01:29Drugs for Treatment of Ulcerative Colitis in IBD
627
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
627