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Laboratory Scale Production and Purification of a Therapeutic Antibody
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[Research progress of IgG4 in isotype selection of antibody drugs]

Chen Chen, Hui Wang, Jing-shuang Wei

    Yao Xue Xue Bao = Acta Pharmaceutica Sinica
    |November 11, 2015
    PubMed

    Many specific therapeutic antibody drugs have been developed for different indications. In drug development, it has been found that the antibody isotype framework can not only affect the physical and chemical properties of therapeutic antibodies, but also influence the activity and therapeutic effect. As a result, IgG isotype selection should be considered carefully in antibody drug development strategies. Because of the unique biological characteristics, IgG4 isotype has been used in some therapeutic antibodies for which effector functions are not desired. In order to provide new ideas for the development of antibody drugs, the research and application progress of IgG4 isotype in therapeutic antibody drug development has been reviewed.

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