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Antioxidant and antithrombotic therapies for diabetic kidney disease

Wenjun Yan, Baoqin Zhou, Yunfeng Shen

  • 1Department of Nephrology, Second Affiliated Hospital, Nanchang University, Nanchang, China. gaosixu@163.com.

Iranian Journal of Kidney Diseases
|November 11, 2015
PubMed

Insights

Diabetic kidney disease (DKD) treatments show promise. Novel antioxidant and antithrombotic therapies, including pancreatic kallikrein, reduce key markers and offer future therapeutic strategies for DKD patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD).
  • Conventional therapies have not altered the increasing incidence of DKD.
  • Novel therapeutic strategies are needed to manage DKD progression.

Purpose of the Study:

  • To review and analyze antioxidant and antithrombotic treatments for DKD.
  • To identify promising novel therapeutic strategies for diabetic kidney disease.

Main Methods:

  • Systematic assessment and meta-analysis of relevant articles on antioxidant and antithrombotic treatments in DKD.
  • Evaluation of treatment efficacy based on meta-analysis results.

Main Results:

  • Pancreatic kallikrein significantly reduced glycated hemoglobin in DKD patients (mean difference, 0.36%).
  • Novel agents like pancreatic kallikrein, sulodexide, Tripterygium wilfordii, and lumbrokinase show beneficial effects.
  • Antioxidant and antithrombotic treatments demonstrate positive outcomes in DKD management.

Conclusions:

  • Antioxidant and antithrombotic treatments are beneficial for DKD patients.
  • These treatments represent promising future therapeutic strategies for managing diabetic kidney disease.
  • Novel agents offer improved therapeutic potential beyond conventional methods.

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