Gastrointestinal tract infection in immunocompromised hosts

The recent regognition of AIDS has stimulated the development of newer cytotoxic therapies and hematological support system which have prolonged the life of these immunocompromised subjects. Moreover, greater number of patients are being recognised who are susceptible to various opportunistic infections involving the GI tract. In view of the poor anti-inflammatory response and minimal signs and symptoms of infection, the diagnosis of these organisms is often difficult. Hence a proper knowledge of the predisposing conditions and meticulous attention to minor symptoms and thorough physical examination alone can lead to an early diagnosis of infection. The common infectious agents include cryptosporiodium, herps virus cytomegalovirus and Giardia. Since, a satisfactory treatment is not available for many of these pathogens, attention should be paid to preventive measures while injudicious use of broadspectrum antibiotics must be checked to prevent superinfections.