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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
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[Blastic plasmacytoid dendritic cell neoplasm: two case reports].

Mohamed Kaabar1, Pierre Lemaire1, Kamel Laribi1

  • 1Laboratoire d'hématologie, Centre hospitalier du Mans, France.

Annales De Biologie Clinique
|November 11, 2015
PubMed
Summary

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive leukemia. This report details two BPDCN cases, highlighting clinical presentation, diagnostic challenges, and therapeutic considerations for this uncommon hematologic malignancy.

Keywords:
5-azacytidineleukemiaplasmocytoid dendritic cell

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Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy.
  • It is characterized by aggressive clinical behavior and frequent cutaneous and extracutaneous involvement.

Observation:

  • Two cases of BPDCN diagnosed at the Hospital Center of Le Mans are presented.
  • The cases involved a 78-year-old woman and an 82-year-old man, both thoroughly documented clinically, biologically, and histologically.

Findings:

  • The report reviews the clinical presentation and diagnostic difficulties associated with BPDCN.
  • Pathogenesis and therapeutic strategies for BPDCN are also discussed.

Implications:

  • This case series contributes to understanding the clinical spectrum of BPDCN.
  • It underscores the importance of recognizing diagnostic challenges and considering therapeutic options for this rare leukemia.