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InterRNA: a database of base interactions in RNA structures.

Sri Devan Appasamy1, Hazrina Yusof Hamdani1, Effirul Ikhwan Ramlan2

  • 1School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia.

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|November 11, 2015
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Summary

The InterRNA database systematically catalogs RNA 3D motifs and base interactions, aiding research into RNA structure and function. This resource enhances understanding of hydrogen bonds critical for RNA stabilization.

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Area of Science:

  • Structural Biology
  • Bioinformatics
  • Molecular Biology

Background:

  • Hydrogen bonds between RNA base residues are crucial for RNA structure stabilization.
  • Investigating large clusters of base interactions requires systematic detection and cataloging.

Purpose of the Study:

  • To introduce InterRNA, a database for known RNA 3D motifs and base clusters interconnected by hydrogen bonds.
  • To facilitate the investigation of biological relevance for RNA base interactions.

Main Methods:

  • Compiled records from RNA structural annotations generated by NASSAM and COGNAC computer programs.
  • Systematically detected, cataloged, and compared RNA 3D motifs and hydrogen-bonded base clusters.

Main Results:

  • The InterRNA database contains comprehensive records of RNA 3D motifs and base interactions.
  • Analysis shows InterRNA extends annotations for known motifs and identifies novel interactions.

Conclusions:

  • InterRNA serves as a valuable resource for RNA structural research.
  • The database facilitates further investigations into RNA 3D motifs and base interactions.