Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.8K
3.8K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

19.0K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
19.0K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

15.2K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
15.2K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

5.3K
5.3K
MicroRNAs01:22

MicroRNAs

24.6K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A TAD-informed aging-brain xQTL atlas of multi-modal and cell-type-resolved regulatory variation.

medRxiv : the preprint server for health sciences·2026
Same author

The mRNA covalent modification dihydrouridine regulates transcript turnover and photosynthetic capacity during plant abiotic stress.

The Plant cell·2026
Same author

QQS as a dual-mode regulator of carbon and nitrogen allocation in Arabidopsis.

Plant physiology and biochemistry : PPB·2026
Same author

Machine-learning identified suicide risk and emergency department inpatient admission.

General hospital psychiatry·2026
Same author

Integrated Multi-Omic Analyses Uncover a Regulatory Link Between Photosynthesis and Drought Tolerance in Field-Grown Sorghum.

Plant, cell & environment·2026
Same author

Functionally informed annotation influences pathway-specific polygenic risk and disease inference in Alzheimer's disease.

medRxiv : the preprint server for health sciences·2026
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Mar 30, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

24.8K

DASHR: database of small human noncoding RNAs.

Yuk Yee Leung1, Pavel P Kuksa1, Alexandre Amlie-Wolf2

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Penn Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.

Nucleic Acids Research
|November 11, 2015
PubMed
Summary
This summary is machine-generated.

The new Database of small human noncoding RNAs (DASHR) unifies comprehensive gene and mature RNA data for small non-coding RNAs (sncRNAs). This resource aids researchers in exploring sncRNA regulation across human tissues.

More Related Videos

Identification of Functionally-Relevant Lentivirus Integration Sites in an Insertional Mutagenesis Cell Library
07:28

Identification of Functionally-Relevant Lentivirus Integration Sites in an Insertional Mutagenesis Cell Library

Published on: January 10, 2025

775
Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos
08:37

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

Published on: October 9, 2020

6.0K

Related Experiment Videos

Last Updated: Mar 30, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

24.8K
Identification of Functionally-Relevant Lentivirus Integration Sites in an Insertional Mutagenesis Cell Library
07:28

Identification of Functionally-Relevant Lentivirus Integration Sites in an Insertional Mutagenesis Cell Library

Published on: January 10, 2025

775
Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos
08:37

Preparation of Small RNA Libraries for Sequencing from Early Mouse Embryos

Published on: October 9, 2020

6.0K

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Small non-coding RNAs (sncRNAs) are crucial regulators of cellular processes.
  • Existing databases lack unified annotation and expression data for sncRNA transcripts and products.
  • Thousands of sncRNA genes exist in the human genome, necessitating a centralized resource.

Purpose of the Study:

  • To introduce the Database of small human noncoding RNAs (DASHR), a comprehensive resource for sncRNA research.
  • To provide researchers with a unified platform for accessing sncRNA gene and mature product information.
  • To facilitate the study of sncRNA regulation, processing, and expression across human tissues.

Main Methods:

  • Integration of annotation data from multiple public sources.
  • Inclusion of 187 small RNA high-throughput sequencing (smRNA-seq) datasets.
  • Development of a user-friendly interface for data visualization and comparison.

Main Results:

  • DASHR (v1.0) annotates approximately 48,000 human sncRNA genes and mature products.
  • 82% of annotated sncRNAs are expressed in at least one curated human tissue.
  • The database covers major sncRNA classes including miRNAs, piRNAs, sn/sno/scRNAs, tRNAs, and rRNAs.

Conclusions:

  • DASHR provides the most comprehensive information available on human sncRNA genes and products.
  • The database enables detailed analysis of sncRNA sequence, structure, expression, and processing.
  • DASHR serves as a valuable tool for advancing research into sncRNA function and regulation.