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Homocysteine in Chronic Heart Failure

Pauline Fournier, Joelle Fourcade, Jérome Roncalli

    Clinical Laboratory
    |November 12, 2015
    PubMed

    Insights

    Hyperhomocysteinemia (HHcy) is common in chronic heart failure (CHF) patients and predicts mortality. Elevated homocysteine (Hcy) levels indicate a higher risk of death within five years.

    Area of Science:

    • Cardiology
    • Biochemistry
    • Clinical Medicine

    Background:

    • Hyperhomocysteinemia (HHcy) is a known cardiovascular disease risk factor.
    • Homocysteine (Hcy) generates reactive oxygen species, contributing to oxidative stress and chronic heart failure (CHF) progression.

    Purpose of the Study:

    • To evaluate the predictive value of plasma homocysteine (Hcy) levels in patients with chronic heart failure (CHF).
    • To investigate the relationship between Hcy levels and other clinical markers in CHF patients.

    Main Methods:

    • 134 adult CHF patients underwent echocardiography, 6-min walk test, and VO(2max) determination.
    • Serum Hcy levels and other markers were measured, with clinical follow-up at five years.

    Main Results:

    • CHF patients exhibited markedly elevated Hcy levels (18.4 ± 7.83 μmol/L) compared to controls (12.8 ± 3.14 μmol/L).
    • Hcy correlated negatively with VO(2max) and positively with BNP. Patients with HHcy > 15 μmol/L had significantly lower 5-year survival rates (35% vs. 56%).
    • HHcy and hs-CRP were identified as independent predictors of 5-year mortality.

    Conclusions:

    • HHcy is prevalent in CHF patients and significantly associated with increased 5-year mortality risk.
    • Homocysteine (Hcy) can serve as an additional clinical risk marker for CHF patients, aiding in risk stratification and management.
    Abstract

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