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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
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Benzene oxide is a substrate for glutathione S-transferases

Adam T Zarth1, Sharon E Murphy2, Stephen S Hecht1

  • 1Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA; Medicinal Chemistry Graduate Program, University of Minnesota, Minneapolis, MN, USA.

Chemico-Biological Interactions
|November 12, 2015
PubMed
Summary

Glutathione S-transferases (GSTs) detoxify benzene oxide (BO), a carcinogen. GSTT1 and GSTP1 show significant activity, with GSTT1 being critical for BO detoxification, while GSTA1 and GSTM1 appear less important.

Keywords:
Benzene oxideDetoxificationGSTP1GSTT1Glutathione S-transferaseKinetics

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