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Oncogenic Signaling Adaptor Proteins

Leo Y Luo1, William C Hahn2

  • 1Health Sciences and Technology Program, Harvard Medical School, Boston, MA 02115, USA.

Journal of Genetics and Genomics = Yi Chuan Xue Bao
|November 12, 2015
PubMed

Insights

Adaptor proteins CRKL, GAB2, and FRS2 are newly identified oncogenes. Amplification of these genes drives lung and ovarian cancers, highlighting them as potential therapeutic targets.

Area of Science:

  • Molecular biology
  • Cancer genetics
  • Signal transduction

Background:

  • Receptor tyrosine kinases (RTKs) activate critical cell signaling pathways.
  • Adaptor proteins scaffold key signaling events downstream of RTKs.
  • Recent genomic studies reveal adaptor proteins as novel oncogenes.

Purpose of the Study:

  • To review the discovery, structure, function, and therapeutic potential of three adaptor oncogenes: CRKL, GAB2, and FRS2.
  • To highlight the role of these adaptor proteins in cancer development.

Main Methods:

  • Integration of structural and functional genomic approaches.
  • Analysis of gene amplification in cancer cell lines.
  • In vitro and in vivo transformation assays.

Main Results:

  • CRKL, GAB2, and FRS2 are recurrently amplified in lung adenocarcinoma and ovarian cancer.
  • These amplified genes are essential for cancer cell line survival.
  • Overexpression transforms immortalized human cell lines.

Conclusions:

  • Adaptor proteins represent a distinct class of oncogenes.
  • These adaptor oncogenes are crucial drivers of specific cancers.
  • CRKL, GAB2, and FRS2 are promising therapeutic targets for cancer treatment.
Keywords:
Adaptor proteinCancerOncogene

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