Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

113.4K
Overview
113.4K
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

11.6K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
11.6K
Receptor-Mediated Endocytosis01:20

Receptor-Mediated Endocytosis

5.7K
5.7K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

4.9K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
4.9K
Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

20.7K
Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
20.7K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

3.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure-Based Discovery of Potent BCL-XL Inhibitors through Rescaffolding.

Journal of medicinal chemistry·2026
Same author

Editorial: Understanding effective education: far transfer from a sociocultural and cognitive neural perspective.

Frontiers in psychology·2026
Same author

Rhythmic high-amplitude delta with superimposed spikes (RHADS): a treatment dilemma.

Oxford medical case reports·2024
Same author

Complete genome sequences of sucrose non-fermenting non-O1/non-O139 <i>Vibrio cholerae</i> isolated from human soft tissue infection.

Microbiology resource announcements·2024
Same author

Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of qualitative evidence.

The Cochrane database of systematic reviews·2024
Same author

Dual plating in the metastatic distal humerus: Benefits may outweigh the risks.

Journal of orthopaedics·2024

Related Experiment Video

Updated: Mar 30, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with &#946;-arrestin
13:45

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

13.3K

TLX: An elusive receptor.

Cindy Benod1, Rosa Villagomez1, Paul Webb1

  • 1Department of Genomic Medicine, Houston Methodist Research Institute (HMRI), 6670 Bertner Avenue, Houston, TX 77030, USA.

The Journal of Steroid Biochemistry and Molecular Biology
|November 12, 2015
PubMed
Summary

Tailless receptor (TLX) is a nuclear receptor target for neurological disorders. Identifying TLX ligands is crucial for understanding its function and developing new therapies for brain conditions.

Keywords:
CoregulatorDruggabilityNuclear receptorProtein-protein interaction surfaceSmall moleculeStructure-based drug design

More Related Videos

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

10.2K
Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy
09:24

Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy

Published on: January 30, 2020

8.7K

Related Experiment Videos

Last Updated: Mar 30, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with &#946;-arrestin
13:45

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin

Published on: December 23, 2010

13.3K
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

10.2K
Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy
09:24

Visualizing Surface T-Cell Receptor Dynamics Four-Dimensionally Using Lattice Light-Sheet Microscopy

Published on: January 30, 2020

8.7K

Area of Science:

  • Molecular biology
  • Neuroscience
  • Pharmacology

Background:

  • The tailless receptor (TLX) is a nuclear receptor lacking identified ligands.
  • TLX is a significant therapeutic target for neurological disorders and brain tumors.
  • Recent findings indicate TLX is druggable, necessitating further research.

Purpose of the Study:

  • To review the current understanding of TLX ligand binding and its role in gene transcription.
  • To discuss strategies for identifying potent and specific TLX ligands.
  • To explore the structural basis for TLX ligand design and coregulator interactions.

Main Methods:

  • Literature review of nuclear receptor research.
  • Analysis of structural and functional studies on TLX.
  • Discussion of potential therapeutic strategies targeting TLX.

Main Results:

  • TLX is a promising drug target, but its ligands and mechanisms remain largely uncharacterized.
  • Understanding the TLX ligand-binding domain is key for designing effective therapeutics.
  • Elucidating TLX coregulator interactions is essential for context-specific drug development.

Conclusions:

  • Further research into TLX ligands and coregulators is vital for its therapeutic validation.
  • Ligand design must advance alongside a deeper understanding of TLX's molecular mechanisms.
  • This review highlights key areas for future investigation in TLX-targeted drug discovery.