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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Selective Ruthenium-Catalyzed Reductive Alkoxylation and Amination of Cyclic Imides
Jose R Cabrero-Antonino1, Iván Sorribes1, Kathrin Junge1
1Leibniz-Institut für Katalyse e.V., Albert-Einstein-Str. 29a, 18059 Rostock (Germany).
Abstract:
Reported herein, for the first time, is the selective ruthenium-catalyzed reductive alkoxylation and amination of phthalimides/succinimides. Notably, this novel methodology avoids hydrogenation of the aromatic ring and allows methoxylation of substituted imides with good to excellent selectivity for one of the carbonyl groups. The reported method opens the door to the development of new processes for the selective synthesis of various functionalized N-heterocyclic compounds. As an example, intramolecular reductive couplings to afford tricyclic compounds are presented for the first time.
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