Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

400
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
400
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

387
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
387
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

358
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
358
Hypertension I: Introduction01:28

Hypertension I: Introduction

1.2K
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
1.2K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

891
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
891
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

690
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
690

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-hypertensive therapy reduced the incidence of stroke in older patients with isolated systolic hypertension.

Evidence-based cardiovascular medicine·2005
Same author

Evaluation and correction for a 'training effect' in the cognitive assessment of older adults.

Neuroepidemiology·2002
Same author

Physical exercise and the prevention of disability in activities of daily living in older persons with osteoarthritis.

Archives of internal medicine·2001
Same author

Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile.

Circulation·2001
Same author

Blood-pressure-lowering treatment.

Lancet (London, England)·2001
Same author

Dementia and disability outcomes in large hypertension trials: lessons learned from the systolic hypertension in the elderly program (SHEP) trial.

American journal of epidemiology·2001
Same journal

The Role of Telemedicine on Interhospital Transfer Outcomes : A Systematic Review.

Annals of internal medicine·2026
Same journal

Prolonged Short Sleep and Its Effect on Body Weight and Composition : A Pooled Analysis of Randomized Trials.

Annals of internal medicine·2026
Same journal

In AF, LAAC was noninferior to NOAC therapy for a composite efficacy outcome and reduced non-procedure-related bleeding at 3 y.

Annals of internal medicine·2026
Same journal

How AI is affecting medical journals.

Annals of internal medicine·2026
Same journal

In adults with COPD, the BLISS score predicted risk for acute respiratory hospital admission at 2 y.

Annals of internal medicine·2026
Same journal

In AF at risk for stroke and bleeding, LAAC was not noninferior to medical therapy for a composite of thromboembolic and safety events.

Annals of internal medicine·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.6K

Hypertension in elderly patients.

W B Applegate1

  • 1University of Tennessee, Memphis.

Annals of Internal Medicine
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Treating diastolic hypertension in elderly patients up to age 80 is beneficial, reducing cardiovascular events. However, treatment for isolated systolic hypertension in the elderly requires more data, and side effects must be managed.

More Related Videos

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.3K

Related Experiment Videos

Last Updated: May 5, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.6K
Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.3K

Area of Science:

  • Geriatrics
  • Cardiology
  • Epidemiology

Background:

  • Hypertension is a significant risk factor for cardiovascular morbidity and mortality in the elderly.
  • Elevated systolic blood pressure is a stronger predictor of adverse cardiovascular outcomes in older adults than diastolic blood pressure.

Purpose of the Study:

  • To synthesize current information on the epidemiology, pathophysiology, and management of hypertension in the elderly.
  • To provide guidance for physicians on treatment decisions for elderly hypertensive patients.

Main Methods:

  • Comprehensive literature search of English-language articles from MEDLINE (1972-1988) and review of textbooks and articles.
  • Inclusion of primary research, with emphasis on large randomized clinical trials concerning hypertension in the elderly.
  • Assessment of study design, quality, subject selection, sample size, outcome variables, and clinical applicability.

Main Results:

  • Epidemiologic data indicate a stronger correlation between elevated systolic blood pressure and cardiovascular events in the elderly.
  • Randomized trials demonstrate that treating diastolic hypertension in patients up to age 80 yields significant cardiovascular risk reduction.
  • The European Working Party on Hypertension in the Elderly reported a 27% relative reduction in cardiovascular mortality with drug treatment.
  • Insufficient data exist to definitively recommend treatment for isolated systolic hypertension in the elderly.

Conclusions:

  • Treatment of mild to moderate diastolic hypertension in the elderly provides significant cardiovascular risk reduction.
  • The absolute benefit of treating diastolic hypertension must be weighed against potential serious side effects.
  • Further research is needed to establish optimal management strategies for isolated systolic hypertension in older adults.