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Enhanced gentamicin killing of Escherichia coli by tet gene expression
T L Merlin1, D L Corvo, J H Gill
1Laboratory Service, Albuquerque Veterans Administration Medical Center, New Mexico 87108.
Antimicrobial Agents and Chemotherapy
|February 1, 1989
Abstract:
Time-kill studies were performed to determine the effect of tetracycline resistance (tet) gene expression on gentamicin killing of Escherichia coli. Expression of tet increased gentamicin killing in laboratory strains and clinical isolates. A role for tetracycline in inducing tet expression and increasing the bactericidal activity of aminoglycosides is suggested.