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Updated: Mar 30, 2026
10:43
High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
Published on: November 5, 2016
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Polysaccharide-based antibiofilm surfaces
Guy-Alain Junter1, Pascal Thébault1, Laurent Lebrun1
1CNRS, UMR 6270, PBS Laboratory, Normandie Univ, UR, 76821 Mont-Saint-Aignan cedex, France.
Acta Biomaterialia
|November 12, 2015
Summary
Polysaccharide coatings offer a promising strategy to prevent biofilm infections on medical implants. Recent advancements focus on natural polymers like ulvan and chitosan for anti-adhesive and bactericidal surface treatments.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Microbiology
Background:
- Implant-associated biofilm infections pose significant challenges in medicine, food, and cosmetics.
- Polysaccharides, abundant natural polymers, exhibit inherent antibiofilm properties.
Purpose of the Study:
- To review polysaccharide-based surface coatings developed in the last decade to prevent biofilm formation.
- To highlight anti-adhesive and bactericidal strategies for material surfaces.
Main Methods:
- Survey of recent literature on polysaccharide coatings for antibiofilm applications.
- Focus on natural polysaccharides like hyaluronic acid, heparin, ulvan, and chitosan.
Main Results:
- Hyaluronic acid and heparin coatings demonstrate hydrophilic properties.
- Ulvan (an algal polysaccharide) shows promising anti-adhesive capabilities.
- Chitosan and its derivatives, particularly in layer-by-layer assemblies with other polysaccharides, offer both anti-adhesive and bactericidal effects.
Conclusions:
- Polysaccharide-based surface treatments represent a viable approach to combat biofilm contamination.
- The review provides updated information on advanced polysaccharide antibiofilm surfaces.
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