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Related Concept Videos

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Related Experiment Video

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High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
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Published on: November 5, 2016

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Polysaccharide-based antibiofilm surfaces.

Guy-Alain Junter1, Pascal Thébault1, Laurent Lebrun1

  • 1CNRS, UMR 6270, PBS Laboratory, Normandie Univ, UR, 76821 Mont-Saint-Aignan cedex, France.

Acta Biomaterialia
|November 12, 2015
PubMed
Summary
This summary is machine-generated.

Polysaccharide coatings offer a promising strategy to prevent biofilm infections on medical implants. Recent advancements focus on natural polymers like ulvan and chitosan for anti-adhesive and bactericidal surface treatments.

Keywords:
Bacterial adhesionBactericidal coatingBiomaterialChitosanSurface functionalization

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Microbiology

Background:

  • Implant-associated biofilm infections pose significant challenges in medicine, food, and cosmetics.
  • Polysaccharides, abundant natural polymers, exhibit inherent antibiofilm properties.

Purpose of the Study:

  • To review polysaccharide-based surface coatings developed in the last decade to prevent biofilm formation.
  • To highlight anti-adhesive and bactericidal strategies for material surfaces.

Main Methods:

  • Survey of recent literature on polysaccharide coatings for antibiofilm applications.
  • Focus on natural polysaccharides like hyaluronic acid, heparin, ulvan, and chitosan.

Main Results:

  • Hyaluronic acid and heparin coatings demonstrate hydrophilic properties.
  • Ulvan (an algal polysaccharide) shows promising anti-adhesive capabilities.
  • Chitosan and its derivatives, particularly in layer-by-layer assemblies with other polysaccharides, offer both anti-adhesive and bactericidal effects.

Conclusions:

  • Polysaccharide-based surface treatments represent a viable approach to combat biofilm contamination.
  • The review provides updated information on advanced polysaccharide antibiofilm surfaces.