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[Epidemiology, diagnosis and treatment of Middle East respiratory syndrome]

Yu Zhang1, Shao-hua Chen2

  • 1Department of Oncology, Zhejiang Hospital, Hangzhou 310013 China.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences
|November 12, 2015
PubMed

Insights

Middle East respiratory syndrome (MERS) is a global health concern. Understanding MERS coronavirus (MERS-CoV) transmission and pathogenesis is crucial for developing effective prevention strategies.

Area of Science:

  • * Virology
  • * Epidemiology
  • * Public Health

Background:

  • * Middle East respiratory syndrome (MERS) poses a significant global public health risk.
  • * The Middle East respiratory syndrome coronavirus (MERS-CoV) has caused over 1,300 confirmed cases across 26 countries.
  • * MERS-CoV is a zoonotic virus with incompletely understood pathogenesis and transmission routes.

Purpose of the Study:

  • * To summarize the current understanding of MERS-CoV epidemiology and transmission.
  • * To highlight the role of the spike glycoprotein in MERS-CoV infection.
  • * To emphasize the need for prophylactic strategies against MERS-CoV.

Main Methods:

  • * Review of reported MERS-CoV cases and epidemiological data.
  • * Analysis of MERS-CoV transmission patterns, including zoonotic and human-to-human spread.
  • * Examination of the molecular mechanisms of MERS-CoV, focusing on the spike glycoprotein.

Main Results:

  • * As of June 19, 2015, 1,338 MERS-CoV cases were reported globally.
  • * Most cases are linked to travel or residence in the Middle East.
  • * Human-to-human transmission has been observed but is generally not sustainable.

Conclusions:

  • * MERS-CoV remains a public health concern requiring further investigation.
  • * The spike glycoprotein is a key factor in MERS-CoV pathogenesis.
  • * Effective prophylactic strategies are essential for controlling MERS-CoV outbreaks.

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