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Pentoxifylline Loaded Floating Microballoons: Design, Development and Characterization.

Prashant Malik1, Upendra Nagaich1, Raj Kaur Malik1

  • 1Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology, Meerut 250 103, India.

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|November 12, 2015
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Summary
This summary is machine-generated.

Floating microballoons loaded with pentoxifylline were developed to extend drug release in the stomach. Increased polymer concentrations improved buoyancy and drug loading, while slowing release, indicating potential for prolonged gastric residence time.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Floating microballoons offer a strategy for prolonged and uniform drug release in the stomach.
  • Gastric residence time is a critical factor influencing oral drug bioavailability.

Purpose of the Study:

  • To design, develop, and characterize pentoxifylline-loaded floating microballoons.
  • To enhance the gastric residence time of pentoxifylline using floating microballoon technology.

Main Methods:

  • Pentoxifylline microballoons prepared using solvent evaporation technique with HPMC K4M and ethyl cellulose (EC).
  • Characterization included particle size, surface morphology, production yield, loading efficiency, buoyancy, and in vitro drug release.
  • Drug release data analyzed using kinetic models to determine diffusion patterns.

Main Results:

  • Higher polymer concentrations (HPMC K4M, EC) increased particle size, loading efficiency, and buoyancy.
  • Increased polymer content significantly retarded pentoxifylline release.
  • Optimized formulation (F3) showed particle size of 104.0 ± 2.87 µm, yield of 80.89 ± 2.24%, loading efficiency of 77.85 ± 0.61%, buoyancy of 77.52 ± 2.04%, and 82.21 ± 1.29% in vitro release.
  • Drug release followed anomalous (non-Fickian) diffusion kinetics.

Conclusions:

  • The developed floating microballoons successfully prolonged pentoxifylline release.
  • Formulation composition, particularly the ratio of HPMC K4M to EC, significantly impacts drug release kinetics.
  • This technology holds promise for improving oral drug delivery by extending gastric residence time.