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Systemic vasculitis in association with human immunodeficiency virus infection
L H Calabrese1, M Estes, B Yen-Lieberman
1Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, OH 44106.
Arthritis and Rheumatism
|May 1, 1989
Summary
This study reports a case of benign lymphocytic angiitis in a patient with human immunodeficiency virus (HIV). The findings suggest a spectrum of lymphoproliferative disorders in HIV disease causing systemic necrotizing vasculitis.
Area of Science:
- Immunology
- Pathology
- Virology
Background:
- Vasculitis associated with human immunodeficiency virus (HIV) infection is rare.
- Previous cases include angiocentric immunoproliferative disorders like lymphomatoid granulomatosis and angiocentric lymphoma.
Observation:
- A case of benign lymphocytic angiitis of T cell lineage in an HIV-infected patient is presented.
- Extensive studies revealed no viral antigens in inflammatory infiltrates.
- Immunologic evaluation showed predominantly CD3+, CD8+, CD4- T cells with T cell receptor determinant deletion.
Findings:
- The case represents benign lymphocytic angiitis, a T cell-mediated lymphoproliferative disorder.
- The findings suggest a spectrum of such disorders in HIV disease.
- These disorders can manifest as systemic necrotizing vasculitis.
Implications:
- Clinicians should consider this spectrum of lymphoproliferative disorders in HIV patients presenting with vasculitis.
- Early recognition and management are crucial for patient outcomes.
- Further research is needed to elucidate the exact mechanisms driving these conditions.