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[Properties and activation mechanism of neutrophilic leukocytes]
M Baggiolini1, D A Deranleau, B Dewald
1Theodor-Kocher-Institut, Universität Bern, Schweiz.
Arzneimittel-Forschung
|January 1, 1989
Abstract:
The mechanism of neutrophil activation by chemotactic receptor agonists was studied by monitoring stimulus-induced changes in the cytosolic free calcium concentration and hydrogen peroxide formation during the respiratory burst. Two receptor-dependent signal transduction sequences were identified. One sequence depends on calcium, phospholipase C and protein kinase C, and is rate limiting, while the other is comparatively fast and appears to be calcium-independent. The present studies indicate that both sequences must act in concert to transduce receptor-mediated signals and to activate the NADPH oxidase.