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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

109
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
109
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

250
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
250
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

118
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
118
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

302
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
302
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

212
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
212
Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

128
Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
128

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Lipid-Based Drug Delivery Systems.

Hina Shrestha1, Rajni Bala1, Sandeep Arora1

  • 1Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway, Rajpura, Patiala, Punjab 140401, India.

Journal of Pharmaceutics
|November 12, 2015
PubMed
Summary
This summary is machine-generated.

Lipid-based drug delivery systems (LBDDS) enhance the bioavailability and solubility of poorly water-soluble drugs. These versatile formulations offer tailored solutions for various administration routes and can reduce drug toxicity.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biopharmaceutics

Background:

  • Lipid-based drug delivery systems (LBDDS) are crucial for improving the bioavailability of poorly water-soluble drugs.
  • Lipids offer a promising approach for overcoming solubility and absorption challenges in drug formulation.
  • The application of LBDDS is expanding due to the increasing variety of active pharmaceutical ingredients.

Purpose of the Study:

  • To review novel lipid-based formulations, including emulsions, vesicular systems, and lipid particulate systems.
  • To highlight the diverse applications of these advanced lipid-based systems in pharmaceutical drug delivery.
  • To discuss the potential of LBDDS in enhancing drug efficacy and reducing toxicity.

Main Methods:

  • Review of current literature on lipid-based drug delivery systems.
  • Categorization of novel lipid-based formulations (emulsions, vesicular systems, lipid particulates).
  • Analysis of formulation characteristics and application-specific advantages.

Main Results:

  • Lipid-based formulations can be customized for various routes of administration (oral, topical, parenteral, pulmonary).
  • These systems effectively enhance solubility and bioavailability of challenging drug compounds.
  • Lipid formulations demonstrate potential in reducing drug toxicity by altering biodistribution.

Conclusions:

  • Novel lipid-based formulations represent a significant advancement in pharmaceutical drug delivery.
  • LBDDS provide a commercially viable strategy for formulating diverse pharmaceuticals.
  • Further exploration of lipid-based systems is warranted for optimizing drug therapy and patient outcomes.