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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

761
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
216
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
844
Oral Drug Delivery Systems: Delayed-Release Systems01:11

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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FDA-Approved Natural Polymers for Fast Dissolving Tablets.

Md Tausif Alam1, Nayyar Parvez1, Pramod Kumar Sharma1

  • 1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Plot No. 2, Sector 17-A, Yamuna Expressway, Gautam Buddh Nagar, Greater Noida, Uttar Pradesh 201306, India.

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Summary

Natural polymers offer safe and effective alternatives for fast-dissolving tablets, overcoming challenges like dysphagia. These FDA-approved materials enhance drug delivery and patient compliance.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Oral drug administration is preferred for safety, convenience, and cost-effectiveness.
  • Fast-dissolving tablets offer advantages over conventional forms, particularly for patients with swallowing difficulties (dysphagia).
  • Natural polymers present benefits over synthetic alternatives, including inertness, non-toxicity, affordability, and biodegradability.

Purpose of the Study:

  • To review FDA-approved natural polymers for use in fast-dissolving tablets.
  • To highlight the advantages of natural polymers in pharmaceutical formulations.

Main Methods:

  • Literature review of natural polymers used in fast-dissolving tablets.
  • Analysis of properties and applications of natural polymers such as locust bean gum, banana powder, mango peel pectin, Mangifera indica gum, and Hibiscus rosa-sinenses mucilage.

Main Results:

  • Natural polymers can act as binders, diluents, and superdisintegrants in tablet formulations.
  • These polymers improve drug solubility, reduce disintegration time, and offer nutritional benefits.
  • Specific natural polymers enhance tablet properties and patient acceptance.

Conclusions:

  • Natural polymers are safe, efficacious, cost-effective, and eco-friendly alternatives to synthetic polymers in fast-dissolving tablets.
  • Their use addresses limitations of conventional dosage forms and improves drug delivery.
  • FDA-approved natural polymers are valuable in developing advanced oral dosage forms.