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Related Experiment Video

Updated: Mar 30, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Roel Vink¹, Menno V Huisman

¹Tergooi, afd. Intensive Care, Hilversum.

Nederlands Tijdschrift Voor Geneeskunde

|November 12, 2015

Summary

This summary is machine-generated.

Forgoing bridging anticoagulation in atrial fibrillation patients undergoing procedures reduced bleeding risk without increasing clot risk, according to the BRIDGE trial. However, its applicability to high-risk patients remains uncertain.

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Area of Science:

Cardiology
Clinical Trials
Pharmacology

Background:

Managing anticoagulation during invasive procedures presents a challenge, balancing thromboembolism risk against bleeding risk.
Interrupting anticoagulation increases thromboembolism risk, while bridging with short-acting anticoagulants raises peri-operative bleeding concerns.

Purpose of the Study:

To evaluate the efficacy and safety of forgoing bridging anticoagulation versus peri-operative bridging in patients with atrial fibrillation undergoing elective invasive procedures.

Main Methods:

A randomized controlled trial (the BRIDGE trial) compared a strategy of no bridging anticoagulation to bridging with low-molecular-weight heparin in patients with atrial fibrillation.

Main Results:

Forgoing bridging anticoagulation significantly decreased major bleeding risk.
This strategy was non-inferior to peri-operative bridging for preventing arterial thromboembolism.

Conclusions:

In atrial fibrillation patients with low thromboembolic risk undergoing low bleeding risk procedures, omitting bridging anticoagulation is safe and effective.
The benefit of bridging anticoagulation in moderate to high-risk patients undergoing high bleeding risk procedures requires further investigation.