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Related Concept Videos

Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
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Voltage-gated Ion Channels01:26

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Cardiac Action Potential01:30

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Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
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Ion Channels01:19

Ion Channels

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The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
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Non-gated Ion Channels01:24

Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
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Related Experiment Video

Updated: Mar 30, 2026

Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
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Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry

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Cardiac ion channels.

Birgit T Priest1, Jeff S McDermott1

  • 1a Lilly Research Laboratories ; Indianapolis , IN USA.

Channels (Austin, Tex.)
|November 12, 2015
PubMed
Summary
This summary is machine-generated.

Cardiac ion channels are vital for heart function and drug targets. This review covers their physiology, pharmacology, therapeutic potential, and risks of drug-induced side effects.

Keywords:
arrhythmiacardiac functioncardiomyocyteelectrocardiogramion channelpharmacologyvascular tone

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Area of Science:

  • Cardiology
  • Pharmacology
  • Molecular Biology

Background:

  • Cardiac ion channels regulate essential functions like heart rhythm and contractility.
  • These channels are primary targets for treating cardiac diseases, including atrial fibrillation and angina.
  • Drug interactions with cardiac ion channels can lead to adverse effects.

Purpose of the Study:

  • To review the physiology and pharmacology of key cardiac ion channels.
  • To highlight recent advancements in therapeutic development targeting cardiac ion channels.
  • To elucidate potential mechanisms underlying drug-induced cardiac side effects.

Main Methods:

  • Literature review of cardiac ion channel physiology.
  • Pharmacological analysis of ion channel modulators.
  • Synthesis of recent research on therapeutic applications and drug-induced toxicity.

Main Results:

  • Cardiac ion channels are crucial for normal heart function and disease states.
  • Numerous therapeutic strategies leverage ion channel modulation for cardiovascular conditions.
  • Off-target drug effects on ion channels represent a significant safety concern.

Conclusions:

  • Understanding cardiac ion channel physiology and pharmacology is essential for effective drug development.
  • Targeting cardiac ion channels offers promising therapeutic avenues for cardiovascular diseases.
  • Mitigating drug-induced cardiac side effects requires careful consideration of ion channel interactions.