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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
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Chemotherapy-induced peripheral neuropathy: Current status and progress.

Jamie R Brewer1, Gladys Morrison2, M Eileen Dolan2

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Gynecologic Oncology
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Chemotherapy-induced peripheral neuropathy (CIPN) is a common, long-term side effect impacting cancer survivors' quality of life. This review covers CIPN

Keywords:
ChemotherapyNeuropathyToxicity

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Area of Science:

  • Oncology
  • Neurology
  • Clinical Pharmacology

Background:

  • Increasing cancer survivor population necessitates focus on long-term treatment toxicities.
  • Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and debilitating adverse effect.
  • CIPN significantly impacts patients' quality of life.

Purpose of the Study:

  • To review the clinical presentation, evaluation, and management of CIPN.
  • To focus on CIPN specifically related to platinum and taxane chemotherapy agents.
  • To discuss current models and ongoing research for understanding and treating CIPN.

Main Methods:

  • Literature review of clinical presentations and management strategies for CIPN.
  • Focused analysis of CIPN associated with platinum and taxane agents.
  • Exploration of existing clinical models and research avenues for CIPN.

Main Results:

  • CIPN is a common long-term toxicity of chemotherapy.
  • Platinum and taxane agents are significant contributors to CIPN.
  • Understanding and managing CIPN remains an active area of research.

Conclusions:

  • Effective management and further research into CIPN are crucial for improving cancer survivor care.
  • Targeted approaches for platinum and taxane-induced neuropathy are needed.
  • Advancing research into CIPN mechanisms may lead to novel therapeutic options.