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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Predictors of Stroke After Transient Ischemic Attack in Children
Laura L Lehman1, Christopher G Watson2, Kush Kapur2
1From the Departments of Neurology (L.L.L., C.G.W., K.K., M.J.R.), Psychiatry (M.J.R.), and Radiology (A.R.D., M.J. R.), Boston Children's Hospital, MA; and Departments of Radiology (A.R.D.) and Neurology (L.L.L., M.J.R.), Harvard Medical School, Boston, MA. laura.lehman@childrens.harvard.edu.
Stroke
|November 12, 2015
Summary
Pediatric transient ischemic attack (TIA) carries a stroke risk similar to adults. Key risk factors for stroke after TIA in children include arteriopathy, female sex, and autoimmune disorders.
Area of Science:
- Pediatric Neurology
- Cerebrovascular Diseases
- Pediatric Stroke
Background:
- Transient ischemic attack (TIA) in children is understudied compared to adults.
- Risk factors for subsequent stroke after TIA in pediatric patients are largely unknown.
Purpose of the Study:
- To determine the incidence of stroke following TIA in children.
- To identify risk factors associated with stroke after TIA in pediatric patients.
Main Methods:
- Retrospective review of medical records at Boston Children's Hospital (2009-2010).
- Inclusion criteria: pediatric patients evaluated for TIA with magnetic resonance imaging (MRI).
- Follow-up imaging assessed for subsequent stroke; logistic regression analyzed risk factors.
Main Results:
- 63 children with TIA were identified; 16% developed ischemic cerebral injury.
- 8 children (13%) experienced stroke post-TIA.
- Arteriopathy, female sex, and autoimmune disorders were significantly associated with post-TIA stroke.
Conclusions:
- Stroke incidence after TIA in children is comparable to adults.
- Risk factors for stroke after TIA in children differ from those in adults.
