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Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity.

Somi Kim1, TaeHyun Kim1, Hye-Ryeon Lee1

  • 1Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
|November 12, 2015
PubMed
Summary

Mind bomb-2 (Mib2) deletion in mice impairs spatial memory and synaptic plasticity. This suggests Mib2 is crucial for adult brain function via Notch signaling.

Keywords:
HippocampusMemoryMind bomb-2Notch signalingSynaptic plasticity

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • Notch signaling regulates neuronal development but its adult brain function is unclear.
  • Mind bomb-2 (Mib2) is essential for Notch pathway signaling in signal-sending cells.

Purpose of the Study:

  • To investigate the role of Mib2 in the adult mouse brain.
  • To understand Notch signaling's role in neuronal cell-cell interactions and function.

Main Methods:

  • Genetic deletion of Mib2 in the mouse brain.
  • Behavioral tests for spatial memory and contextual fear.
  • Electrophysiological analysis of hippocampal synaptic plasticity.
  • Western blot analysis of Notch1 levels.

Main Results:

  • Mib2 knockout (KO) mice exhibited impaired spatial and contextual fear memory.
  • Hippocampal synaptic plasticity was reduced in Mib2 KO mice.
  • Basal synaptic transmission remained unchanged, but cleaved Notch1 levels decreased post-stress in KO mice.

Conclusions:

  • Mib2 is critical for hippocampal synaptic plasticity and memory formation in adult mice.
  • The Notch signaling pathway, regulated by Mib2, is vital for these cognitive functions.
  • Mib2's role extends beyond development to adult brain physiology.