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Angiomodulatory properties of Rhodiola spp. and other natural antioxidants
Dorota M Radomska-Leśniewska1, Piotr Skopiński2, Barbara J Bałan3
1Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Abstract:
Disturbances of angiogenesis and oxidative stress can lead to many serious diseases such as cancer, diabetes or ischemic heart disease. Substances neutralizing oxidative stress are known as antioxidants. They can affect angiogenesis process also, and thus, they modulate therapy results. Antioxidants become more and more frequently used in order to maintain homeostasis of the organism and diminish the risk of disease. Herein, we introduce some antioxidant preparations of natural plant origin (Rhodiola, Aloe vera, Resveratrol, Echinacea, Plumbagin) and antioxidant supplements (Padma 28, Reumaherb, Resvega). Analyses of their angiogenic properties, their multidirectional molecular effect on angiogenesis as well as medical application are within the scope of this review. Most of presented preparations down regulate neovascularization. They can be safely administered to patients with abnormally high angiogenesis. Rhodiola modulates, and Echinacea, Aloe vera and Plumbagin inhibit tumour-related angiogenesis in vitro and in vivo (animal models). Resveratrol and Resvega reduce neovascularization in the eye and may be applicable in eye disorders. Padma 28 preparation exhibits angioregulatory activity, decreasing high angiogenesis of cancer cells and increasing physiological angiogenesis, therefore can be used in therapy of patients with various disturbances of angiogenesis. Antioxidant application in the case of angiogenesis-related diseases should take into consideration angiogenic status of the patient.
Insights
Antioxidants, used to combat oxidative stress, can modulate angiogenesis, impacting disease treatment. This review analyzes natural and supplemental antioxidants for their effects on blood vessel formation and therapeutic potential in angiogenesis-related diseases.
Area of Science:
- Biochemistry
- Pharmacology
- Cell Biology
Background:
- Disturbances in angiogenesis and oxidative stress are linked to diseases like cancer, diabetes, and ischemic heart disease.
- Antioxidants neutralize oxidative stress and can influence angiogenesis, potentially affecting therapeutic outcomes.
- The use of antioxidants is increasing for maintaining homeostasis and reducing disease risk.
Purpose of the Study:
- To review the angiogenic properties and molecular effects of various natural and supplemental antioxidants.
- To analyze the medical applications of these antioxidants in managing angiogenesis-related conditions.
- To evaluate the safety and efficacy of antioxidants in patients with abnormal angiogenesis.
Main Methods:
- Review of scientific literature on antioxidant preparations and their effects on angiogenesis.
- Analysis of in vitro and in vivo (animal models) studies.
- Examination of clinical applications and safety profiles.
Main Results:
- Most reviewed antioxidants down-regulate neovascularization and can be safely used in patients with high angiogenesis.
- Rhodiola modulates, while Echinacea, Aloe vera, and Plumbagin inhibit tumor-related angiogenesis.
- Resveratrol and Resvega reduce ocular neovascularization, and Padma 28 exhibits angioregulatory activity, beneficial for various angiogenesis disturbances.
Conclusions:
- Antioxidants possess significant potential in managing angiogenesis-related diseases.
- The choice of antioxidant therapy should consider the patient's specific angiogenic status.
- Further research into the precise molecular mechanisms and clinical efficacy is warranted.
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