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The Non-Obese Diabetic Mouse Strain as a Model to Study CD8(+) T Cell Function in Relapsing and Progressive Multiple
Prenitha Mercy Ignatius Arokia Doss1, Andrée-Pascale Roy1, AiLi Wang1
1Department of Neurosciences, Centre de recherche du CHU de Québec - Université Laval (Pavillon CHUL) , Québec, QC , Canada.
Frontiers in Immunology
|November 12, 2015
Summary
CD8(+) T cells accumulate in the central nervous system during progressive multiple sclerosis (MS). Understanding their role in experimental autoimmune encephalomyelitis (EAE) models is crucial for developing new MS therapies.
Area of Science:
- Neuroimmunology
- Autoimmune Diseases
Background:
- Multiple sclerosis (MS) is a neurodegenerative disease caused by autoimmune attack on central nervous system (CNS) myelin.
- While CD4(+) T cells are studied, CD8(+) T cells also play a significant role in MS pathology.
- CD8(+) T cells accumulate in the CNS in progressive MS, a form resistant to current therapies.
Purpose of the Study:
- To discuss the function of CD8(+) T cells in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS.
- To highlight the utility of EAE in non-obese diabetic (NOD) mice for modeling progressive MS.
- To examine a specific transgenic mouse model (1C6) for studying T cell subsets in CNS autoimmunity.
Main Methods:
- Utilizing experimental autoimmune encephalomyelitis (EAE) as a mouse model for multiple sclerosis (MS).
- Employing non-obese diabetic (NOD) background mice to study a progressive disease pattern.
- Characterizing a transgenic mouse strain (1C6) with T cells targeting MOG[35-55].
Main Results:
- EAE in NOD mice mimics the relapsing-remitting and progressive phases of human MS.
- The 1C6 transgenic model allows for simultaneous study of CD4(+) and CD8(+) T cell responses.
- This model provides insights into the distinct roles of T cell subsets in CNS autoimmunity.
Conclusions:
- CD8(+) T cells are critical players in the pathogenesis of multiple sclerosis.
- The described mouse models offer valuable tools for dissecting T cell functions in CNS autoimmunity.
- Further research using these models can inform the development of targeted MS therapies.
