Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

2.2K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.2K
Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

29
The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
29
Development of Human Microbiota01:30

Development of Human Microbiota

34
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
34
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

68
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
68
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

3.4K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.4K
Sputum Studies II: Culture and Sensitivity01:20

Sputum Studies II: Culture and Sensitivity

1.7K
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrative multi-omic analyses identify major axes of heterogeneity in chronic obstructive pulmonary disease and uncover their molecular contributors.

medRxiv : the preprint server for health sciences·2026
Same author

Impact of obstructive lung disease and sleep apnea symptoms on cardiovascular risk and all-cause mortality: insights from a community-dwelling cohort.

Sleep & breathing = Schlaf & Atmung·2026
Same author

Whole genome sequencing of the pulmonary microbiome in interstitial lung disease subtypes.

Respiratory research·2025
Same author

The Burden of COPD with Type 2 Inflammation in North-West Continental Europe.

International journal of chronic obstructive pulmonary disease·2025
Same author

Inflammatory cells and remodeling in bronchial biopsies from COPD patients and controls.

PloS one·2025
Same author

Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED.

Health and quality of life outcomes·2024

Related Experiment Video

Updated: Mar 30, 2026

Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome
07:38

Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome

Published on: August 3, 2021

2.9K

The Bergen COPD microbiome study (MicroCOPD): rationale, design, and initial experiences.

Rune Grønseth1, Ingvild Haaland2, Harald G Wiker3

  • 1Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.

European Clinical Respiratory Journal
|November 12, 2015
PubMed
Summary

This study investigates the respiratory microbiome in individuals with and without chronic obstructive pulmonary disease (COPD). High-quality sampling methods are used to analyze the lower airways microbiota and its relation to disease development and the immune system.

Keywords:
COPDbiopsiesbronchoscopycontrol subjectsinflammationmicrobiomeremodeling

More Related Videos

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

9.7K
Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
11:23

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples

Published on: December 22, 2014

37.8K

Related Experiment Videos

Last Updated: Mar 30, 2026

Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome
07:38

Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome

Published on: August 3, 2021

2.9K
The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

9.7K
Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
11:23

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples

Published on: December 22, 2014

37.8K

Area of Science:

  • Microbiology
  • Pulmonology
  • Immunology

Background:

  • Emerging evidence suggests respiratory microbiota varies with airway disease status.
  • New sequencing methods reveal microorganisms in non-infected airways.

Purpose of the Study:

  • Establish high-quality lower airways microbiota sampling methods.
  • Describe the respiratory microbiome in chronic obstructive pulmonary disease (COPD) patients and controls.
  • Correlate the microbiome with disease development, progression, and host immunity.

Main Methods:

  • Longitudinal study (MicroCOPD) with 200 COPD subjects and 150 controls.
  • Bronchoscopy with protected specimen brushes, small-volume lavage, bronchoalveolar lavage, and biopsies.
  • Analysis of microbiota and host immune status linked to clinical and follow-up parameters.

Main Results:

  • Over 150 bronchoscopies completed, balanced between cases and controls.
  • Low complication rate observed during procedures.

Conclusions:

  • The MicroCOPD study will yield significant data on the respiratory microbiome.
  • Provides novel insights into the role of the microbiome in respiratory health and disease.