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Liver transplantation.

J M Neuberger, D H Adams

    Bailliere'S Clinical Gastroenterology
    |January 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Liver transplantation is now a viable treatment for end-stage liver disease, with 1-year survival rates around 70%. Despite challenges like high 30-day mortality and postoperative complications, it

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    Area of Science:

    • Hepatology
    • Transplant Surgery
    • Gastroenterology

    Background:

    • Liver transplantation is increasingly accepted for end-stage liver disease.
    • Indications for liver transplantation are expanding, including acute liver failure.
    • Transplantation for liver cancer is decreasing due to high recurrence rates.

    Purpose of the Study:

    • To review the current status and challenges of liver transplantation.
    • To evaluate the efficacy and limitations of liver transplantation as a treatment modality.
    • To discuss the evolving indications and clinical problems in liver transplantation.

    Main Methods:

    • Review of current literature and clinical outcomes in liver transplantation.
    • Analysis of survival rates, indications, and complications.

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  • Assessment of patient selection criteria and surgical improvements.

    • Main Results:

    • Achieved 1-year survival rates of approximately 70%.
    • High 30-day mortality (around 30%) persists, with infection and rejection as major postoperative complications.
    • Excellent rehabilitation observed in most patients post-transplantation.

    Conclusions:

    • Liver transplantation is an established treatment, not experimental, for end-stage liver disease.
    • Candidate selection and timing remain critical challenges.
    • Ongoing improvements in surgical and anesthetic techniques are noted, but complications require continued management.