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Hepatocellular adenoma: An update.

Adarsh Vijay1, Ahmed Elaffandi1, Hatem Khalaf1

  • 1Adarsh Vijay, Hatem Khalaf, Hamad Medical Corporation, Doha 3050, Qatar.

World Journal of Hepatology
|November 12, 2015
PubMed
Summary

Hepatocellular adenomas (HCAs) are rare liver tumors. Advances aid early detection, but diagnosis and management remain challenging due to rarity, impacting evidence-based guidelines.

Area of Science:

  • Hepatology
  • Oncology
  • Molecular Biology

Background:

  • Hepatocellular adenomas (HCAs) are rare benign liver tumors.
  • Early identification is improving with technology, but precise diagnosis of hepatocellular incidentalomas is challenging.
  • Molecular insights are revealing new aspects of HCA genetics and pathophysiology.

Purpose of the Study:

  • To provide a comprehensive review of hepatocellular adenomas (HCAs).
  • To discuss the etiology, molecular biology, pathophysiology, clinical manifestations, and complications of HCAs.
  • To elaborate on genetic advancements, diagnostic tools, and current management guidelines for HCAs.

Main Methods:

  • Literature review of etiology, molecular biology, pathophysiology, clinical manifestations, complications, genetics, diagnostics, and management of HCAs.
Keywords:
Benign liver lesionFocal liver lesionLiver adenoma

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  • Analysis of recent technological advancements in early identification of liver lesions.
  • Synthesis of current evidence for management recommendations and guidelines.

    • Main Results:

    • HCA diagnosis remains challenging despite technological advancements.
    • Molecular studies offer new insights into HCA genetics and pathophysiology.
    • The rarity of HCAs limits the evidence quality for current management guidelines.

    Conclusions:

    • Comprehensive understanding of HCA etiology, molecular biology, and pathophysiology is crucial.
    • Genetic advancements are improving diagnostic capabilities.
    • Current management guidelines require further evidence due to tumor rarity.