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Overactive bladder syndrome: Current pathophysiological concepts and therapeutic approaches.
Nadir I Osman1, Christopher R Chapple1
1Department of Urology, Royal Hallamshire Hospital, Sheffield, UK.
Arab Journal of Urology
|November 12, 2015
Summary
Overactive bladder syndrome (OAB) affects 10-20% of the population. Current treatments include anti-muscarinics, beta-3 agonists, botulinum toxin, and neuromodulation, offering management options for this challenging condition.
Area of Science:
- Urology
- Pharmacology
Background:
- Overactive bladder syndrome (OAB) is a prevalent condition impacting quality of life.
- OAB affects 10-20% of the general population.
- The definition and understanding of OAB pathogenesis are still evolving.
Purpose of the Study:
- To review contemporary reports on OAB pathogenesis.
- To provide an update on current therapeutic approaches for OAB.
Main Methods:
- A systematic literature search was conducted on the PUBMED database.
- Publications from January 1985 to May 2013 were included.
- Keywords included 'overactive bladder', 'anti-muscarinics', 'β-3 agonists', 'botulinum toxin', 'tibial nerve stimulation', and 'sacral neuromodulation'.
Main Results:
- 33 articles were selected for this review.
- Anti-muscarinic agents are the primary pharmacotherapy for OAB.
- Beta-3 agonists offer an alternative for patients intolerant to anti-muscarinics.
- Intravesical botulinum toxin and sacral neuromodulation are effective options for refractory OAB.
Conclusions:
- Overactive bladder syndrome presents a significant management challenge due to incomplete understanding.
- A diverse range of therapeutic options is available for OAB management.
- Further research is needed to optimize treatment parameters, especially for botulinum toxin therapy.
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