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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury
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Stem cells therapy for ALS.

Letizia Mazzini1, Angelo Vescovi2,3, Roberto Cantello4

  • 1a ALS Centre, Department of Neurology , Maggiore della Carità University Hospital , Novara , Italy.

Expert Opinion on Biological Therapy
|November 13, 2015
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for amyotrophic lateral sclerosis (ALS). Further research is needed to optimize cell-based treatments and clinical trial protocols for safety and efficacy, focusing on patient quality of life.

Keywords:
Amyotrophic lateral sclerosisneuroinflammationneuroprotectionstem cell

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Despite advances in understanding amyotrophic lateral sclerosis (ALS) molecular basis, effective therapeutics remain elusive.
  • Stem cell technologies offer potential for novel ALS treatments.

Purpose of the Study:

  • To review the therapeutic potential of various stem cells for ALS.
  • To identify challenges and open questions in the clinical translation of stem cell therapies for ALS.

Main Methods:

  • Detailed discussion of preclinical and clinical studies on stem cell therapy for ALS.
  • Analysis of current challenges in translating stem cell research into clinical practice.

Main Results:

  • Stem cell (SC) therapy presents a promising avenue for ALS treatment.
  • Mesenchymal stem cells and neural fetal stem cells demonstrate safety and potential efficacy.
  • Further rigorous studies are required to confirm long-term safety and efficacy.

Conclusions:

  • Optimizing cell-based treatments and clinical trial implementation for ALS is critical.
  • A coordinated, multicenter international clinical program is essential for refining transplantation procedures and protocols.
  • Cost-benefit analyses must prioritize patient quality of life as a key outcome measure.