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Cardiovascular risk in pulmonary alveolar proteinosis
Effrosyni D Manali1, Georgia Papadaki1, Dimitrios Konstantonis2
1a 2nd Pulmonary Department , "Attikon" University Hospital, Athens Medical School, National and Kapodistrian University of Athens , Athens , Greece.
Expert Review of Respiratory Medicine
|November 13, 2015
Summary
Pulmonary alveolar proteinosis (PAP) patients show cardiac dysfunction indicators linked to lung disease severity. Further research is needed to quantify cardiovascular risk in PAP.
Area of Science:
- Cardiology
- Pulmonology
- Internal Medicine
Background:
- Pulmonary alveolar proteinosis (PAP) is a rare lung disorder.
- Cardiovascular complications are not well-established in PAP patients.
Purpose of the Study:
- To investigate potential increases in cardiovascular events and cardiac dysfunction indices in PAP patients.
- To explore the relationship between lung disease severity and cardiovascular risk markers in PAP.
Main Methods:
- Studied 13 PAP patients (median age 47) assessing serum anti-GM-CSF antibodies, disease severity score (DSS), echocardiography, and cardiac biomarkers (troponin, pro-BNP).
- Analyzed relationships between cardiac markers, lung function tests (DLCO%, TLC%), and demographic/clinical parameters.
Main Results:
- Troponin levels directly correlated with disease severity score (DSS), age, and cardiac dimensions.
- Disease severity score (DSS) was the strongest predictor of troponin levels (R² = 0.776, p = 0.007).
- No cardiovascular events occurred during follow-up, but cardiac risk indices were linked to lung disease severity.
Conclusions:
- In PAP, cardiovascular risk indicators are associated with the severity of lung disease.
- PAP patients may face an elevated risk for cardiovascular events, warranting further investigation.
Keywords:
Pulmonary alveolar proteinosisautoimmune pulmonary alveolar proteinosiscardiovascular eventsdisease severityinhaled GM-CSFpro-BNPpulmonary arterial hypertensionserum lipidstroponinMore Related Videos
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