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Customizable 3D Printed 'Plug and Play' Millifluidic Devices for Programmable Fluidics.

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Three dimensional (3D) printing enables programmable liquid handling and control of biological samples using novel milli-fluidic structures. This technology allows for the creation of modular devices for complex fluidic operations, reproducible by anyone with a 3D printer.

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Area of Science:

  • Biotechnology
  • Microfluidics
  • 3D Printing

Background:

  • Three dimensional (3D) printing is a rapidly advancing technology for fabricating complex structures.
  • Fused Deposition Modeling (FDM) has been previously used for 3D chemical fluidic systems.

Purpose of the Study:

  • To demonstrate the construction of 3D milli-fluidic structures for programmable liquid handling and biological sample control.
  • To develop modular, inter-connectable fluidic devices using 3D printing.

Main Methods:

  • Utilized Fused Deposition Modeling (FDM)-based 3D printing.
  • Developed water-in-oil (W/O) droplet generators for monodisperse droplet production.
  • Integrated sensors for online monitoring of cellular growth.
  • Employed chemical surface treatment for valve-based flow selectors.

Main Results:

  • Successfully constructed 3D milli-fluidic structures for precise liquid handling.
  • Demonstrated compartmentalized droplet generation and online cellular growth monitoring.
  • Created valve-based flow selectors and inter-connectable modular fluidic devices.
  • Enabled complex operations like mixing, flow control, and reaction monitoring.

Conclusions:

  • 3D printed milli-fluidic structures offer a versatile platform for biological sample manipulation and analysis.
  • The developed modular components facilitate the networking of fluidic systems.
  • This technology democratizes the creation of custom fluidic devices, promoting wider accessibility and reproducibility.