Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interface-engineered Caco-2 cell culture on a collagen-coated liquid-liquid interface in a microfluidic device.

Beilstein journal of nanotechnology·2026
Same author

Association Between Individual Functional Movement Screen™ Tasks and Sports Injury Occurrence in University Basketball Players: A Prospective Cohort Study.

International journal of sports physical therapy·2026
Same author

Endometriosis-Associated Ovarian Carcinosarcoma Featuring Well-Differentiated Adenocarcinoma and Fetal Rhabdomyoma-Like Mesenchymal Components: An Unusual Case Report-With Molecular Analysis.

Case reports in pathology·2026
Same author

Pregnancy-related acute myocardial infarction after treatment with ritodrine hydrochloride: A case report.

Case reports in women's health·2026
Same author

Hearing characteristics of Branchio-oto-renal syndrome in Japan.

Acta oto-laryngologica·2026
Same author

The intrinsic impact of mechanical stress on the maintenance of oocyte dormancy.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Mar 30, 2026

Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip
08:35

Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip

Published on: December 29, 2015

9.2K

Cancer Cell Analyses at the Single Cell-Level Using Electroactive Microwell Array Device.

Marina Kobayashi1,2, Soo Hyeon Kim1,2, Hiroko Nakamura1,2

  • 1Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.

Plos One
|November 13, 2015
PubMed
Summary
This summary is machine-generated.

This study introduces a microfluidic device for analyzing rare circulating tumor cells (CTCs) in blood. The method uses dielectrophoretic forces to isolate and analyze single cells for improved cancer metastasis detection.

More Related Videos

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform
09:24

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

9.7K
Simplified, High-throughput Analysis of Single-cell Contractility using Micropatterned Elastomers
14:33

Simplified, High-throughput Analysis of Single-cell Contractility using Micropatterned Elastomers

Published on: April 8, 2022

4.1K

Related Experiment Videos

Last Updated: Mar 30, 2026

Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip
08:35

Electrotaxis Studies of Lung Cancer Cells using a Multichannel Dual-electric-field Microfluidic Chip

Published on: December 29, 2015

9.2K
Assembly and Tracking of Microbial Community Development within a Microwell Array Platform
09:24

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

9.7K
Simplified, High-throughput Analysis of Single-cell Contractility using Micropatterned Elastomers
14:33

Simplified, High-throughput Analysis of Single-cell Contractility using Micropatterned Elastomers

Published on: April 8, 2022

4.1K

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Cancer Research

Background:

  • Circulating tumor cells (CTCs) are crucial for cancer metastasis.
  • Analyzing CTCs in blood is challenging due to their rarity and mixture with other blood cells.

Purpose of the Study:

  • To develop a novel microfluidic method for single-cell analysis of cell mixtures.
  • To enable high-throughput biochemical analyses of rare cells like CTCs.

Main Methods:

  • Utilizing a microfluidic device with arrayed electroactive microwells.
  • Employing dielectrophoretic (DEP) force for efficient single-cell trapping and positioning.
  • Performing on-chip analyses including immunostaining, viability/apoptosis assays, and FISH.

Main Results:

  • Demonstrated successful trapping and stable positioning of single cells using DEP force.
  • Showcased the feasibility of various biochemical assays at the single-cell level on the chip.
  • Validated the method's potential for analyzing rare cells within complex mixtures.

Conclusions:

  • The proposed microfluidic method facilitates discrimination and analysis of rare circulating tumor cells.
  • This approach offers a powerful tool for high-throughput single-cell analysis in cancer research.
  • The technique simplifies the study of rare cells, aiding in metastasis detection and characterization.