Related Experiment Video
Updated: Mar 30, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Effect of Intraperitoneal Thymoquinone on Postoperative Peritoneal Adhesions
Z Bozdag1, M Gumus, Z Arıkanoglu
1Department of General Surgery, Diyarbakir Dicle University Faculty of Medicine, Yenisehir-Diyarbakir, Turkey.
Background:
To determine the effect of thymoquinone on adhesion formation in a rat caecotomy/suture model.
Material And Methods:
Thirty wistar rats were randomized into three groups: The control group received saline and the thymoquinone group received 10 mg/kg thymoquinone after cecal caecotomy/suture model. In the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were classified, and histopathological samples were taken.
Results:
There were no incisional hernias or wound dehiscences. In comparing adhesion scores, a significant difference was found between the thymoquinone and the control groups (p < 0.05). The grade of inflammation for the thymoquinone and the sham groups were significantly lower than that of the control group (p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham and thymoquinone groups compared to the control group (p < 0.05).
Conclusions:
Based on the results of this study in a rat peritoneal adhesion model, intraperitoneal administered thymoquinone has a strong anti-adhesive effect.
More Related Videos
20:33A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
Published on: July 4, 2019
09:00Application of Straight-needle, Three-tailed, Knot-free, Peritoneal Sutures in Laparoscopic Transabdominal Preperitoneal Hernia Repair
Published on: November 12, 2021