Optimising Breast Conservation Treatment for Multifocal and Multicentric Breast Cancer: A Worthwhile Endeavour?

Area of Science:

• Oncology
• Surgical Oncology
• Breast Cancer Research

Background:

• Breast conservation treatment (BCT) is a standard for early breast cancer.
• Multifocal and multicentric breast cancer (MFMCBC) is often considered a contraindication for BCT.
• This study evaluates BCT feasibility and outcomes in MFMCBC.

Purpose of the Study:

• To compare BCT rates between MFMCBC and unifocal breast tumors.
• To assess the oncological outcomes of BCT in MFMCBC patients.

Main Methods:

• Retrospective analysis of 160 breast cancer patients treated between 2009-2011.
• Defined successful BCT as achieving clear margins for all foci via a single incision with good cosmetic results.
• Compared BCT rates and outcomes in 40 MFMCBC cases versus unifocal tumors.

Main Results:

• BCT was performed in 85% (34/40) of MFMCBC patients.
• No local recurrences were observed in MFMCBC patients after a mean follow-up of 55 months.
• Successful BCT was achieved with clear margins and acceptable cosmesis.

Conclusions:

• BCT is achievable in a high percentage of MFMCBC cases (85%) with no evidence of poorer local control.
• These findings suggest BCT may be a viable option for select MFMCBC patients.
• Further studies are warranted to confirm these results and investigate potential improvements in survival outcomes.