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Physiological and biochemical measurements before, during and after pregnancy of healthy rats
Silvana Barroso Corvino1, Gustavo Tadeu Volpato2, Nathália Cristine Dias Macedo3
1Botucatu Medical School, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Purpose:
To analyze the physiological and biochemical measurements before, during and after pregnancy of healthy rats.
Methods:
Wistar adult females rats (n=8) were weighed and blood samples were obtained before, during and after pregnancy for biochemical determinations, chow intake, water consumption and milk production were evaluated. At day 10 postpartum, the rats were killed for weighing of organs and adipose tissues.
Results:
The results showed increase in body weight, serum insulin and ingestion of water and chow. At day 17 pregnancy, presented normal values in the OGTT. At days 7, 14 and 20 of pregnancy, there was increase in triglyceride levels. At term pregnancy, there was weight gain due to fetal growth. In the postpartum period presented reduced blood glucose levels. The glycemic means were reduced during and after pregnancy compared to after pregnancy. The triglyceride concentrations were increased before and during pregnancy in relation to after pregnancy. The total cholesterol levels presented no changes.
Conclusion:
The use of experimental animals is suitable for evaluation of metabolic changes because the profile of answers found in this study was similar to human profile, showing the relevance of translational research to better understand the pathophysiological mechanisms and possible treatment for diseases.
