Related Experiment Video

Updated: Mar 30, 2026

Effects of Different Connection Modes of Electroacupuncture on Electrocardiogram and Nerve Discharge in Rats
04:33

Effects of Different Connection Modes of Electroacupuncture on Electrocardiogram and Nerve Discharge in Rats

Published on: January 3, 2025

760

Hemodiafiltration and hemodialysis differently affect P wave duration and dispersion on the surface electrocardiogram

Alida Páll1, Árpád Czifra1, Veronika Sebestyén1

  • 1Division of Emergency Medicine, Faculty of Medicine, Clinical Center, Institute of Medicine, University of Debrecen, Nagyerdei krt. 98, P.O. Box 19, 4032, Debrecen, Hungary.

International Urology and Nephrology
|November 13, 2015
PubMed

Insights

Hemodiafiltration (HDF) may be more beneficial than hemodialysis (HD) for reducing atrial arrhythmias, as indicated by improved P wave duration and P dispersion. These findings suggest HDF may offer a better approach for managing arrhythmias in patients undergoing renal replacement therapy.

Area of Science:

  • Nephrology
  • Cardiology
  • Electrophysiology

Background:

  • Atrial fibrillation incidence increases with hemodialysis (HD).
  • Effects of hemodiafiltration (HDF) on atrial arrhythmias remain unevaluated.
  • P wave duration and P dispersion (Pd) predict atrial arrhythmias.

Purpose of the Study:

  • To evaluate the effects of HDF versus conventional HD on atrial electrophysiological markers.
  • To assess the relationship between electrolyte changes, atrial dimensions, and arrhythmias during HDF and HD.

Main Methods:

  • 30 patients underwent HDF for 3 months, followed by conventional HD for at least 3 months.
  • Collected data included electrolyte levels, surface ECG, echocardiography, and Holter ECG.
  • Analyzed P wave duration, P dispersion (Pd), left atrial diameter, and supraventricular premature beats.

Main Results:

  • P wave duration and Pd significantly increased during HD but not HDF.
  • Left atrial diameter decreased significantly during HDF, correlating with reduced supraventricular premature beats.
  • HDF showed significant correlations between sodium changes and Pd, and HD between ionized calcium and Pd.

Conclusions:

  • HDF demonstrates a more beneficial effect on P wave duration and Pd compared to HD.
  • ECG alterations during renal replacement therapy may stem from electrolyte imbalances and the method used.
Abstract

Keywords:
ArrhythmiasAtrial fibrillationHemodiafiltrationHemodialysisP wave dispersion

More Related Videos

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.1K
High-Throughput Analysis of Optical Mapping Data Using ElectroMap07:36

High-Throughput Analysis of Optical Mapping Data Using ElectroMap

Published on: June 4, 2019

10.2K

Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1.8K
Electrocardiogram01:29

Electrocardiogram

An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
7.8K
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
3.2K
ECG Interpretation of Rhythms01:24

ECG Interpretation of Rhythms

An electrocardiogram (ECG)graphically represents the heart's electrical activity on ECG paper or a monitor.
Components of the Electrocardiogram
The primary components of a normal ECG waveform in Normal sinus rhythm(NSR) include the P wave, PR interval, QRS complex, ST segment, T wave, and occasionally a U wave.
ECG waveforms are divided by vertical and horizontal lines at standard intervals.
The horizontal axis measures time and rate, and the vertical axis measures amplitude or voltage....
18.6K
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
861
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
2.2K