Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cannabidiol improves learning and memory deficits and alleviates anxiety in 12-month-old SAMP8 mice.

PloS one·2025

Same author

Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR).

The journal of nutrition, health & aging·2025

Same author

Gut microbiota disturbances in hospitalized older adults with malnutrition and clinical outcomes.

Nutrition (Burbank, Los Angeles County, Calif.)·2024

Same author

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.

The Journal of biological chemistry·2023

Same author

Low circulating adropin levels in late-middle aged African Americans with poor cognitive performance.

npj aging·2023

Same author

Anorexia of aging: An international assessment of healthcare providers' knowledge and practice gaps.

Journal of cachexia, sarcopenia and muscle·2023

Search research articles

Related Experiment Video

Updated: Mar 30, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Nutrient interface with biology and aging.

Tommy Cederholm¹, John E Morley

¹aDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University bDepartment of Geriatric Medicine, Uppsala University Hospital, Uppsala, Sweden cDivisions of Geriatric Medicine and Endocrinology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

Current Opinion in Clinical Nutrition and Metabolic Care

|November 13, 2015

Summary

This summary is machine-generated.

Successful aging involves a Mediterranean diet, exercise, and avoiding smoking. Recent research questions the benefits of weight loss and antioxidant supplements in older adults, highlighting evolving nutritional needs.

More Related Videos

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

Related Experiment Videos

Last Updated: Mar 30, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

Area of Science:

Gerontology
Nutritional Science
Molecular Biology

Background:

Aging is a complex biological process influenced by nutrition and lifestyle.
Established recommendations for healthy aging are being re-evaluated.
Emerging research reveals new factors impacting the aging process.

Purpose of the Study:

To review current challenges at the intersection of nutrition, biology, and aging.
To discuss recent findings that may alter established nutritional guidelines for older adults.

Main Methods:

Literature review of recent studies on nutrition and aging.
Analysis of conflicting data regarding nutrient intake and health outcomes in elderly populations.
Synthesis of findings on the role of diet, lifestyle, and microbiota in aging.

Main Results:

Mediterranean and plant-based diets, rich in fruits and vegetables, alongside exercise and non-smoking, are key to successful aging.
Recent evidence challenges the benefits of weight loss and antioxidant supplements in older individuals.
The role of ethnicity in vitamin D-binding protein levels affects 25(OH)vitamin D measurement, and gut microbiota may be significant for aging.

Conclusions:

Ongoing scientific discoveries necessitate a re-evaluation of traditional nutritional beliefs for older adults.
Personalized nutrition strategies may be required to optimize healthspan.
Further research is needed to clarify the complex interplay of factors in aging.