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High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

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Published on: April 28, 2022

Microbiota and aging.

Stephan C Bischoff¹

¹Institute of Clinical Nutrition, University of Hohenheim, Stuttgart, Germany.

Current Opinion in Clinical Nutrition and Metabolic Care

|November 13, 2015

Summary

This summary is machine-generated.

The gut microbiota changes with age, impacting elderly health and increasing disease risk. Interventions like probiotics and prebiotics may help reverse these aging-related alterations.

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Gerontology
Microbiology
Immunology

Background:

Aging is associated with significant alterations in the intestinal microbiota.
These microbial shifts contribute to 'inflamm-aging', a state of chronic, low-grade inflammation linked to age-related diseases.

Purpose of the Study:

To summarize current knowledge on age-related changes in the intestinal microbiota.
To explore the implications of these changes for health and disease in the elderly and centenarians.

Main Methods:

Review of existing literature on intestinal microbiota in aging populations.
Analysis of age-associated microbial shifts and their metabolic consequences.

Main Results:

Age-related changes include an increase in proteolytic bacteria and a decrease in saccharolytic bacteria.
These microbial alterations are linked to sarcopenia, longevity, and increased susceptibility to diseases like cancer and neurological disorders.
Probiotics have shown efficacy in treating infections and enhancing immune responses in the elderly.

Conclusions:

Intestinal microbiota composition changes significantly with age, influencing elderly morbidity and mortality.
Dietary interventions, including prebiotics and probiotics, alongside lifestyle modifications, show potential in mitigating or reversing these age-related microbial alterations.