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A model to decrease hepatic blood flow and cardiac output with pressure breathing.

M W Perkins1, J F Dasta, B DeHaven

  • 1Department of Pharmacy Practice and Administration, Philadelphia College of Pharmacy and Sciences, PA 19104.

Clinical Pharmacology and Therapeutics
|May 1, 1989
PubMed
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Continuous positive airway pressure (CPAP) significantly reduced hepatic blood flow and cardiac index in healthy males. This suggests CPAP impacts circulatory function even in individuals without respiratory conditions.

Area of Science:

  • Cardiology
  • Hepatology
  • Respiratory Physiology

Background:

  • Continuous positive airway pressure (CPAP) is a common treatment for sleep apnea.
  • Its effects on cardiovascular and hepatic function in healthy individuals are not fully understood.

Purpose of the Study:

  • To evaluate the impact of CPAP on hepatic blood flow (HBF) and cardiac output in healthy male subjects.

Main Methods:

  • A randomized, controlled, crossover study design was employed.
  • Ten healthy males received CPAP at 12.5 cm H2O or ambient pressure.
  • Hepatic blood flow was estimated using indocyanine green plasma clearance; cardiac output was measured via Doppler ultrasound.

Main Results:

  • CPAP significantly decreased HBF by 14.1% (p=0.033) in 80% of subjects.

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  • Cardiac index (CI) decreased by 14.1% (p=0.0001) in all subjects.
  • Stroke volume and respiratory rate also decreased significantly, while heart rate remained unchanged.

    • Conclusions:

    • CPAP at 12.5 cm H2O induces a significant reduction in both HBF and CI in healthy males.
    • These findings highlight potential circulatory effects of CPAP beyond its therapeutic applications.