Direct factor Xa inhibitor edoxaban: from bench to clinical practice

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Updated: Mar 30, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

14.5K

Mpa Brekelmans1, S Middeldorp2, M Coppens3

  • 1a Department of Vascular Medicine F4-146 , Academic Medical Center , Amsterdam , The Netherlands.

Expert Review of Hematology
|November 13, 2015
PubMed

Insights

Edoxaban, a direct factor Xa inhibitor, offers effective stroke prevention in atrial fibrillation and venous thromboembolism treatment. It provides similar thromboembolic protection to warfarin with a reduced bleeding risk.

Area of Science:

  • Pharmacology
  • Cardiology
  • Hematology

Background:

  • Edoxaban is a novel direct oral anticoagulant (DOAC) targeting factor Xa.
  • It is the fourth DOAC approved for clinical use.
  • DOACs represent a significant advancement in anticoagulant therapy.

Purpose of the Study:

  • To review the key characteristics of edoxaban.
  • To summarize the clinical evaluation program for edoxaban's regulatory approval.
  • To highlight edoxaban's role in stroke prevention and VTE management.

Main Methods:

  • Review of large Phase III randomized controlled trials.
  • Analysis of clinical data supporting regulatory submissions.
  • Comparison of edoxaban with warfarin and other anticoagulants.

Main Results:

  • Edoxaban demonstrated reduced bleeding risk compared to warfarin.
  • It provided comparable protection against thromboembolic events.
  • Phase III trials formed the basis for its approval in AF and VTE.

Conclusions:

  • Edoxaban is a valuable addition to anticoagulation therapies.
  • Its once-daily dosing and specific dose adjustments enhance its utility.
  • Limitations include specific renal clearance criteria and initial heparin use for acute VTE.

Keywords:
Edoxabanatrial fibrillationdirect oral anticoagulantsvenous thromboembolism

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