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Lessons from black pepper: piperine and derivatives thereof
D Chavarria1, T Silva1, D Magalhães e Silva1
1a CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences , University of Porto , Porto , Portugal.
Expert Opinion on Therapeutic Patents
|November 13, 2015
Summary
Piperine, a natural compound from black pepper, shows promise as a scaffold for new drugs targeting neurological disorders and drug resistance. Further research into piperine derivatives could lead to significant therapeutic advancements.
Area of Science:
- Pharmacology
- Medicinal Chemistry
- Drug Discovery
Background:
- Piperine is a naturally occurring alkaloid found in black pepper (Piper nigrum).
- Extensive research has revealed diverse pharmacological activities of piperine and its derivatives.
- New chemical entities based on the piperine scaffold demonstrate significant therapeutic potential.
Purpose of the Study:
- To review the therapeutic potential of piperine and related derivatives.
- To provide an overview of patented processes and applications from 2000 to 2015.
Main Methods:
- Literature review of scientific publications.
- Analysis of patented processes and applications related to piperine derivatives.
Main Results:
- Piperine derivatives show potential in treating neurological disorders such as epilepsy, Parkinson's disease, depression, and pain.
- Piperine and its analogues inhibit efflux pumps, potentially overcoming drug resistance mechanisms.
- These compounds may enhance the efficacy of antibiotic and anticancer drugs.
Conclusions:
- Piperine is emerging as a privileged scaffold for developing bioactive compounds for various diseases.
- Piperine derivatives offer promising therapeutic applications, particularly in neurology and infectious diseases.
- Continued exploration of the piperine structure holds potential for significant drug discovery advancements.
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