A rare combination of amniotic constriction band with osteogenesis imperfecta
Krupa Hitesh Shah1, Hitesh Shah2
1Department of Obstetrics and Gynaecology, Melaka Manipal Medical College, Manipal University, Manipal, Karnataka, India.
Insights
This report details a rare case of a child with both amniotic bands and osteogenesis imperfecta, both collagen disorders. The findings offer insights into the pathogenesis of these conditions.
Area of Science:
- Genetics
- Developmental Biology
- Orthopedics
Background:
- Amniotic bands and osteogenesis imperfecta are collagen-related disorders.
- Collagen defects underlie both conditions, yet their co-occurrence is rare.
Observation:
- A child presented with multiple amniotic bands affecting limbs.
- The child experienced multiple fractures, bone deformities, osteopenia, and blue sclerae.
Findings:
- The patient had a rare co-occurrence of amniotic bands and osteogenesis imperfecta.
- Treatment included surgical z-plasty for constriction bands and bisphosphonate for osteogenesis imperfecta.
Implications:
- This case highlights the complex interplay of collagen disorders.
- Further research into the shared pathogenesis of these conditions is warranted.
Abstract:
Amniotic constriction bands and osteogenesis imperfecta are disorders arising from a collagen defect. We report a rare association of amniotic bands with osteogenesis imperfecta in a child. The child was born with multiple amniotic bands involving the right leg, both hands and both feet. Multiple fractures of long bones of lower limbs occurred in childhood due to trivial trauma. Deformities of the femur and tibia due to malunion with osteopenia and blue sclerae were present. The patient was treated with z plasty of constriction band of the right tibia and bisphosphonate for osteogenesis imperfecta. This rare association of both collagen diseases may provide further insight for the pathogenesis of these diseases.
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